M. lignano Neoblast Screen 2016.
Mlig_RNA_3_7_v3 transcriptome version. Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano. (2016) Grudniewska M*, Mouton S*, Simanov S, Beltman F, Grelling M, de Mulder K, Arindrarto W, Weissert P, van der Elst S, Berezikov E. eLife 2016;5:e20607. Home Download

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Transcript classification

Neoblast, stringent 357 transcrip clusters obtained by overllaping 'Irradiation' and 'Neoblast' categories
Neoblast 924 transcript clusters enriched in proliferating cells excluding germline
S/G2/M, no gonads 956 transcript clusters enriched in late-S/G2/M cells in all conditions, including intact animals, cut heads and juveniles
Germline 2,739 transcripts enriched in proliferating germline cells
Int S/G2/M 7,124 transcript clusters significantly enriched in late-S/G2/M cells of intact animals
Irradiation 7,277 transcript clusters significantly depleted at all three time points after irradiation (0h vs 12h, 0h vs 24h, 0h vs 72h)

This is the updated analysis based on Mlig_RNA_3_7_v3 transcriptome assembly.

(The numbers on the images are still from the original analysis)

Irradiation timecourse

FACS-based analysis

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